IBX Oxidations for the Synthesis of Substituted 2H-Pyrans
نویسندگان
چکیده
منابع مشابه
B-alkyl Suzuki couplings for the stereoselective synthesis of substituted pyrans.
Unprotected homoallylic alcohols can be directly converted to cis-2,6-disubstituted pyrans by palladium catalyzed B-alkyl Suzuki coupling and subsequent Michael addition.
متن کاملFacile synthesis of novel D-ring modified steroidal dienamides via rearrangement of 2H-pyrans.
A simple and practical method for synthesis of the D-ring modified steroidal dienamides (4a-k) from the steroidal α,α-dicyanoalkene 3 and aldehydes via vinylogous aldol reaction was first reported. By using NaOAc as a base, the desired products were obtained in moderate to good yields in ethanol under mild conditions. All the synthesized steroidal dienamides are new and are currently being eval...
متن کاملSynthesis of (+/-)-brazilin using IBX.
[reaction: see text] A short synthesis of (+/-)-brazilin is reported. This synthesis uses several interesting and underutilized transformations including a regioselective dirhodium-catalyzed aryl C-H insertion, a regioselective IBX phenol --> o-quinone oxidation, a tautomerization of an o-quinone to a p-quinone methide, and an intramolecular aryl cyclization with a p-quinone methide.
متن کاملNo Acid Required: 4π and 6π Electrocyclization Reactions of Dienyl Diketones for the Synthesis of Cyclopentenones and 2H-Pyrans
The 1,6-conjugate addition of nucleophiles to dienyl diketones produces either cyclopentenone or 2H-pyran products with high selectivity through either Nazarov (4π) or 6π electrocyclization, respectively. The outcome of the reaction is dependent upon the nature of the nucleophile used. Nucleophiles that are anionic or easily deprotonated exclusively produce cyclopentenones via Nazarov cyclizati...
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ژورنال
عنوان ژورنال: HETEROCYCLES
سال: 2021
ISSN: 0385-5414
DOI: 10.3987/com-20-s(k)69